Inherited defects of thyroid hormone-cell-membrane transport
نویسندگان
چکیده
منابع مشابه
Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.
Departments of Medicine (S.R., A.M.D., R.E.W.), Pediatrics (S.R., R.E.W.), and Genetics (S.R.), The University of Chicago, Chicago, Illinois 60637; Department of Medicine (J.H.D.B., G.R.W.), Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom; Department of Clinical Sciences and Community Health (P.B.-P., L.P.), University of Milan, Fondazione Ca’ Granda Policlinico (P.B...
متن کاملDefects of Thyroid Hormone Transport in Serum
Inherited abnormalities of thyroid hormone-binding proteins are not uncommon and can predominate in some ethnic groups. They alter the amount of iodothyronines present in serum and, although the concentration of free hormones remains unaltered, routine measurement can give erroneous results. With a single exception, inherited defects in thyroxine-binding globulin (TBG), are X-chromosome linked ...
متن کاملPlasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability.
Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two stereospecific binding sites for each T4 and T3 have been detected in cell membranes and on intact cells from humans and other species. The apparent Michaelis-Menten values of the high-affinity, low-capacity bindin...
متن کاملThyroid Hormone Transport and Actions
Thyroid hormones (TH) are essential for normal development, differentiation growth and metabolism of every cell in the body. The pro-hormone thyroxine (T4) is synthesized by the thyroid follicles together with a small amount of the biologically active hormone triiodothyronine (T3), which derives mainly from tissue T4 deiodination. Approximately 0.03% of total T4 and 0.3% of total T3 in serum ar...
متن کاملThyroid Hormone Serum Transport Proteins
Thyroid hormone (TH) effects are dependent on the quantity of the hormone that reaches the tissues, hormone activation and the availability of unaltered TH receptors in the cells nuclei and cytoplasm. Since TH enters the cell unbound, the concentration of free rather than total hormone reflects more accurately the activity level of TH-dependent processes. Under normal conditions, changes in fre...
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ژورنال
عنوان ژورنال: Current Opinion in Endocrinology & Diabetes and Obesity
سال: 2013
ISSN: 1752-296X
DOI: 10.1097/01.med.0000432531.03233.ad